成人男女av片在线观看,久久精品午夜一区二区福利,闺蜜男友猛撞h花液h深,国产亚洲精品精品精品

產(chǎn)品中心/ products

您的位置:首頁  -  產(chǎn)品中心  -  天然產(chǎn)物  -  天然產(chǎn)物對照品標(biāo)準(zhǔn)品  -  佛司可林Forskolin(Colforsin)

佛司可林Forskolin(Colforsin)

  • 產(chǎn)品型號:
  • 更新時間:2016-08-18

簡要描述:Forskolin(Colforsin) CAS:66575-29-9 佛司可林Forskolin(Colforsin)
Appearance:Off-white to white powder
Assay(HPLC):>98%

產(chǎn)品詳情

Forskolin(Colforsin) CAS:66575-29-9  佛司可林Forskolin(Colforsin) 

Appearance:Off-white to white powder

Assay(HPLC):>98%

Product Name: Forskolin

CAS No.: 66575-29-9

Synonyms: Colforsin; ForsLean; Coleonol; HL 362; L 75-1362B; NSC 357088; NSC 375489; 7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one

 Chemical Name: (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one; [3R-(3α,4aβ,5β,6β,6aα,10α,10aβ,10bα)]-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one; 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-1H-Naphtho[2,1-b]pyran-1-one

Source: From Coleus Forskohlii

Molecular Formula: C22H34O7

Molecular Weight: 410.50

Appearance: Off-white to white powder

Assay(HPLC)≥98%

Biological Activity: Cell-permeable activator of adenylyl cyclase. Hypotensive and vasodilatory agent. Induces neuronal differentiation in stem cells and in several neuroblastoma. Used to reprogram mouse embryonic fibroblasts to induced pluripotent stem cells in combination with three other small molecules. Activates adenylate cyclase leading to an increase in the intracellular concentration of cAMP.

 

 Cyclic AMP (cAMP) is an important signal carrier necessary for the proper biological response of cells to hormones, neurotransmitters, and other extracellular signals. Forskolin is a naturally occurring diterpene that is produced by the Indian Coleus plant (C. forskohlii). It directly activates adenylyl cyclase through its catalytic subunit and is commonly used to raise levels of cAMP in a wide variety of intact cells and tissue preparations. Forskolin binds to adenylyl cyclase in membranes from stably transfected Sf9 cells expressing type 1 adenylyl cyclase with an IC50 value of 41 nM and demonstrates an EC50 value of 0.5 μM in an activation assay assessing formation of cAMP from ATP. Forskolin also interacts with glucose transporters and certain ion channels and has been used for examining adenylyl cyclase expression, regulation, and G protein signaling.

 The major cell-permeable diterpene isolated from the Indian plant Coleus forskohlii. At low doses, it acts as a positive inotropic agent. At higher doses, it serves as a hypotensive and vasodilatory agent due to its actions as a smooth muscle relaxant. No major side effects are observed at effective doses. Forskolins pharmacological activities are due to its activation of adenylate cyclase (EC50 = 4 µM), resulting in increased cAMP levels. The exact mechanism of forskolins positive inotropic effect is unknown but may be related to a cAMP-dependent increase in Na+ permeability that results in indirect augmentation of Ca2+ release. Inhibits MAP kinase in rat renal mesangial cells (IC50 = 25 µM). Also acts as a Hh pathway antagonist. Shown to inhibit apoptosis in cerebellar granule cells and to induce apoptosis in resting human B lymphocytes.

 

 An adenylate cyclase activator and MAP kinase inhibitor. Forskolin is a diterpenoid isolated from Coleus forskohlii, interacts directly with the catalytic subunit of A cyclase (adenylate cyclase), activating the enzyme and raising intracellular levels of cAMP. Forskolin is cell permeable and active in vivo producing positive inotropic, plaet anti-aggregatory and anti-hypertensive effects. Has also been shown to exhibit smooth muscle relaxant activity, decrease in intraocular pressure and the promotion of hormonal release from the pituitary glands. Inhibits MAP kinase, induces phosphorylation of CREB, connexin 43, Bad, ATF-1 and PKB. Forskolin is an inhibitor of AChR.

 Forskolin is a cell permeable diterpenoid isolated from Coleus forskohlii. Cell-permeable diterpenoid that possesses anti-hypertensive, positive inotropic, and adenylyl cyclase activating properties. Many of its biological effects are due to its activation of adenylyl cyclase and the resulting increase in intracellular cAMP concentration.Forskolin effects calcium currents and inhibits MAP kinase.

在線咨詢

留言框

  • 產(chǎn)品:

  • 您的單位:

  • 您的姓名:

  • 聯(lián)系電話:

  • 常用郵箱:

  • 省份:

  • 詳細(xì)地址:

  • 補(bǔ)充說明:

  • 驗證碼:

    請輸入計算結(jié)果(填寫阿拉伯?dāng)?shù)字),如:三加四=7
產(chǎn)品中心
天然產(chǎn)物

CONTACT

辦公地址:中國(上海)自由貿(mào)易試驗區(qū)臨港新片區(qū)新楊公路1666號3幢315室 EMAIL:2885066715@qq.com
掃碼關(guān)注公眾號
版權(quán)所有©2025 凱立德生物醫(yī)藥技術(shù)(上海)有限公司 All Rights Reserved   備案號:滬ICP備15046197號-1   sitemap.xml技術(shù)支持:化工儀器網(wǎng)   管理登陸

TEL:021-58180488

掃碼關(guān)注公眾號
中文人妻熟女乱又乱精品| 凹凸久久人人澡超碰凹凸| 无码日本精品xxxxxxxxx| av视频在线观看| 翁止熄痒禁伦短文合集免费视频| 女局长白白嫩嫩大屁股| 久久国产精品波多野结衣AV| 疼死了大粗了放不进去| 成人做爰高潮a片免费视频| 成人性生交a片免费直播软件| 女人扒开屁股桶爽30分钟高潮| 上司人妻互换中文字幕| 免费观看性生交大片| 欧美人禽性动交异族另类| 最好朋友的老公上我了怎么办| 丰满熟女人妻大乳波多野吉衣 | 人妻 丝袜美腿 中文字幕| 性欧美xxxxx乱极品少妇| 欧美+日本+国产| 巜疯狂的少妇4做爰| 无码无遮挡刺激喷水视频| 大战熟女丰满人妻av| 欧美黑人狂躁日本妞| 久久久久亚洲av无码a片| 久久久久久av无码免费网站下载| 男澡堂洗澡勃起好大一根| 国产特级毛片a片www| spy3wc撒spy3wc撒尿| 老师在办公室被躁到高潮 | 精品久久久久久中文字幕大豆网| 国产97在线 | 亚洲| A片试看120分钟做受视频| 大胸美女被吃奶爽死视频免费| 亚洲av无码乱码国产麻豆| 丰满少妇被猛烈进入a片| 娇妻在客厅被朋友玩得呻吟动漫| 浪货趴办公桌~H揉秘书电影| 故意短裙公交车被强好爽h| 国产肉体xxxx裸体784大胆| 国产自啪免费精品视频浪潮AV| 男s严厉调教女m小说|