成人男女av片在线观看,久久精品午夜一区二区福利,闺蜜男友猛撞h花液h深,国产亚洲精品精品精品

產(chǎn)品中心/ products

您的位置:首頁  -  產(chǎn)品中心  -  天然產(chǎn)物  -  天然產(chǎn)物對照品標(biāo)準(zhǔn)品  -  佛司可林Forskolin(Colforsin)

佛司可林Forskolin(Colforsin)

  • 產(chǎn)品型號:
  • 更新時間:2016-08-18

簡要描述:Forskolin(Colforsin) CAS:66575-29-9 佛司可林Forskolin(Colforsin)
Appearance:Off-white to white powder
Assay(HPLC):>98%

產(chǎn)品詳情

Forskolin(Colforsin) CAS:66575-29-9  佛司可林Forskolin(Colforsin) 

Appearance:Off-white to white powder

Assay(HPLC):>98%

Product Name: Forskolin

CAS No.: 66575-29-9

Synonyms: Colforsin; ForsLean; Coleonol; HL 362; L 75-1362B; NSC 357088; NSC 375489; 7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one

 Chemical Name: (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one; [3R-(3α,4aβ,5β,6β,6aα,10α,10aβ,10bα)]-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one; 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-1H-Naphtho[2,1-b]pyran-1-one

Source: From Coleus Forskohlii

Molecular Formula: C22H34O7

Molecular Weight: 410.50

Appearance: Off-white to white powder

Assay(HPLC)≥98%

Biological Activity: Cell-permeable activator of adenylyl cyclase. Hypotensive and vasodilatory agent. Induces neuronal differentiation in stem cells and in several neuroblastoma. Used to reprogram mouse embryonic fibroblasts to induced pluripotent stem cells in combination with three other small molecules. Activates adenylate cyclase leading to an increase in the intracellular concentration of cAMP.

 

 Cyclic AMP (cAMP) is an important signal carrier necessary for the proper biological response of cells to hormones, neurotransmitters, and other extracellular signals. Forskolin is a naturally occurring diterpene that is produced by the Indian Coleus plant (C. forskohlii). It directly activates adenylyl cyclase through its catalytic subunit and is commonly used to raise levels of cAMP in a wide variety of intact cells and tissue preparations. Forskolin binds to adenylyl cyclase in membranes from stably transfected Sf9 cells expressing type 1 adenylyl cyclase with an IC50 value of 41 nM and demonstrates an EC50 value of 0.5 μM in an activation assay assessing formation of cAMP from ATP. Forskolin also interacts with glucose transporters and certain ion channels and has been used for examining adenylyl cyclase expression, regulation, and G protein signaling.

 The major cell-permeable diterpene isolated from the Indian plant Coleus forskohlii. At low doses, it acts as a positive inotropic agent. At higher doses, it serves as a hypotensive and vasodilatory agent due to its actions as a smooth muscle relaxant. No major side effects are observed at effective doses. Forskolins pharmacological activities are due to its activation of adenylate cyclase (EC50 = 4 µM), resulting in increased cAMP levels. The exact mechanism of forskolins positive inotropic effect is unknown but may be related to a cAMP-dependent increase in Na+ permeability that results in indirect augmentation of Ca2+ release. Inhibits MAP kinase in rat renal mesangial cells (IC50 = 25 µM). Also acts as a Hh pathway antagonist. Shown to inhibit apoptosis in cerebellar granule cells and to induce apoptosis in resting human B lymphocytes.

 

 An adenylate cyclase activator and MAP kinase inhibitor. Forskolin is a diterpenoid isolated from Coleus forskohlii, interacts directly with the catalytic subunit of A cyclase (adenylate cyclase), activating the enzyme and raising intracellular levels of cAMP. Forskolin is cell permeable and active in vivo producing positive inotropic, plaet anti-aggregatory and anti-hypertensive effects. Has also been shown to exhibit smooth muscle relaxant activity, decrease in intraocular pressure and the promotion of hormonal release from the pituitary glands. Inhibits MAP kinase, induces phosphorylation of CREB, connexin 43, Bad, ATF-1 and PKB. Forskolin is an inhibitor of AChR.

 Forskolin is a cell permeable diterpenoid isolated from Coleus forskohlii. Cell-permeable diterpenoid that possesses anti-hypertensive, positive inotropic, and adenylyl cyclase activating properties. Many of its biological effects are due to its activation of adenylyl cyclase and the resulting increase in intracellular cAMP concentration.Forskolin effects calcium currents and inhibits MAP kinase.

在線咨詢

留言框

  • 產(chǎn)品:

  • 您的單位:

  • 您的姓名:

  • 聯(lián)系電話:

  • 常用郵箱:

  • 省份:

  • 詳細(xì)地址:

  • 補(bǔ)充說明:

  • 驗證碼:

    請輸入計算結(jié)果(填寫阿拉伯?dāng)?shù)字),如:三加四=7
產(chǎn)品中心
天然產(chǎn)物

CONTACT

辦公地址:中國(上海)自由貿(mào)易試驗區(qū)臨港新片區(qū)新楊公路1666號3幢315室 EMAIL:2885066715@qq.com
掃碼關(guān)注公眾號
版權(quán)所有©2025 凱立德生物醫(yī)藥技術(shù)(上海)有限公司 All Rights Reserved   備案號:滬ICP備15046197號-1   sitemap.xml技術(shù)支持:化工儀器網(wǎng)   管理登陸

TEL:021-58180488

掃碼關(guān)注公眾號
精品国产青草久久久久福利| 肉欲娇宠(h)皇帝篇31| 蜜臀av无码久久久久久久| 亚洲AV无一区二区三区久久| aaa级精品无码久久久国产片| 看同性男aa片| 男生女生向前冲第六季| 日本美女图片| 人鲁交yazhonghucxx| 太大太长太粗太久太硬了| 性20分钟一次| 国产精品99久久久久久人| 一本久道久久综合狠狠爱| 爱的色放在线播放| 播放男人添女人下边视频| 张栢芝被柔到高潮下不了床| 苍井そら无码av| 成人女人爽到高潮的A片| 狂性xxxx乱大交老女人| 精品人妻一区二区三区浪潮在线| 美女网站色| 国产又粗又黄又爽又硬的图片| 上司人妻被下属侵犯hd| 免费av片| 久久99精品国产麻豆婷婷| 奶水美人双性h美人多汁| 波多野结衣在线观看| 公交车上荫蒂添的好舒服视频| 图片 小说 校园 激情 都市| 国产精品久久久久久精品| 亚洲精品一区二区国产精华液| 日本熟妇毛茸茸| 国产手机精品一区| 国产日产久久高清欧美一区 | 人妻在卧室被老板疯狂进入| 14表妺好紧没带套18分钟| a片在线观看免费| 亡は夫の上司最美人妻| 当着夫的面被夫上司玩弄| sm抽打调教女人光屁股的作文| 男人手伸进我内衣揉我胸到爽|